论文部分内容阅读
为探讨白细胞介素-6（IL-6）在蛛网膜下腔出血（SAH）发病中的作用机制，采用ELISA法动态观察了SAH后CNS犬的血浆，脑脊液白细胞介素-6（IL-6）含量变化．结果：实验组血浆IL-6含量在注血后第4天有轻度升高，与同期对照组比较有显著差异（P＜0．05），注血后30min及第7天则无明显变化（P＜0.05）．实验组脑脊液IL-6含量在第4天和第7天则明显高于同期对照组（P＜0．01）．提示SAH后中枢神经系统免疫激活，可能是SAH后迟发性脑血管痉挛（DCVS）的原因之一.IL-6可能参与了DCVS的形成过程．
To investigate the mechanism of interleukin-6 (IL-6) in the pathogenesis of subarachnoid hemorrhage (SAH), the levels of interleukin-6 (IL-6) in plasma and cerebrospinal fluid ) Content changes. Results: The content of IL-6 in experimental group increased slightly on the 4th day after injection, which was significantly different from the control group at the same period (P <0.05). There was no significant change at 30min and 7th after injection (P <0.05). The level of IL-6 in cerebrospinal fluid of experimental group was significantly higher than that of the control group on the 4th and 7th day (P <0.01). It suggests that central nervous system immune activation after SAH may be one of the causes of delayed cerebral vasospasm (DCVS) after SAH.IL-6 may be involved in the formation of DCVS.