论文部分内容阅读
目的 :了解环境和基因在类风湿关节炎(RheumatoidArthritis ,RA)发病中的相对重要性。设计 :将丹麦双胞胎登记和出院登记记录相结合进行历史性队列研究。同时用丹麦全国性死亡登记来评价本研究的完整性。背景 :以两组人群为基础的全国双胞胎队列研究。参加者 :本研究共向 3 73 3 8例双胞胎发送了有关风湿性疾病的问卷。对本人自报患有RA的患者进行了临床检查并从医院的病历记录中得到证实。主要的测定结果 :同卵双生和异卵双生中与先证者RA的共患率。结果 :问卷回应率为 84 7%。经证实有 13例同卵双生和 3 6例异卵双生者患有RA。在同卵双生对中无共患RA者 ,在异卵双生对中共患RA的有 2对。以捕获 -再捕获方法确认的可能性为78 3 %。与先证者共患率在同卵双生中为 0 (95 %可信区间为 0～ 2 4 7) ,在异卵双生为 8 8(1 9～2 3 7)。结论 :基因在RA发病中仅起次要作用
Objective: To understand the relative importance of environment and genes in the pathogenesis of rheumatoid arthritis (RA). Design: A historical cohort study combining Danish twins registration and discharge registry records. The completeness of the study was also evaluated using the Danish National Register of Deaths. Background: A national twin cohort based on two groups of people. Participants: The present study sent questionnaires on rheumatic diseases to 3 73 8 twins. A clinical examination of the patients I reported as having RA themselves was confirmed from the hospital’s medical record. The main test results: identical twins and fraternal twins and proband RA comorbidity. Results: The questionnaire response rate was 84.7%. 13 cases of identical twins and 36 cases of fraternal twins have been shown to have RA. There were two pairs of RA in the same-twins pair in co-twins without co-occurrence of RA. The probability of capture-recapture method validation was 78.3%. The comorbidity with probands was 0 in identical twins (95% confidence interval 0 to 247), and in fraternal twins 8 8 (1 9 to 2 3 7). Conclusion: Genes play a secondary role in the pathogenesis of RA