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目的对广州市甲型H1N1流感病例密切接触者进行调查,并对隔离医学观察情况进行分析,为制定甲型H1N1流感防控措施提供科学依据。方法对确诊病例进行流行病学调查,确定密切接触者名单并对其进行追踪调查,采取定点医院和定点宾馆集中隔离医学观察的方法对密切接触者进行隔离观察,出现症状者采集咽拭子用real-time RT-PCR方法检测甲型H1N1流感病毒核酸。结果对223例密切接触者进行调查和观察,对其中23例出现症状者进行排查,及时发现3例甲型H1N1流感病例,其余220例均顺利解除隔离。在入境检疫时发现4例输入病例,其密切接触者104人,未发现甲型H1N1流感病例;在自行前往医院就诊时发现2例输入病例,其密切接触者共60人,发现了3例病例。密切接触者追踪调查与集中隔离时发现的3例病例,其密切接触者59人未发现甲型H1N1流感病例。结论对密切接触者进行调查和隔离医学观察是及时发现续发病例,防止疫情进一步传播和扩散的有效措施,病例不同发现方式影响密切接触者的转归。
Objective To investigate the close contacts of influenza A (H1N1) in Guangzhou and to analyze the isolation medical observations to provide a scientific basis for the prevention and control measures of Influenza A (H1N1). Methods Epidemiological investigation of the confirmed cases, to determine the list of close contacts and follow-up survey to take the designated hospitals and fixed-point isolation medical observation of the method of isolation of close contacts were observed, the symptoms were collected throat swab Real-time RT-PCR method for detection of influenza A (H1N1) virus nucleic acid. Results Totally 223 cases of close contacts were investigated and observed. Twenty-three of them were investigated for symptoms and 3 cases of Influenza A (H1N1) were found in time. The remaining 220 cases were successfully separated. In entering the quarantine found that 4 cases of imported cases, the close contact of 104 people, no cases of influenza A H1N1 influenza; in their own visits to the hospital found 2 cases of input, the close contacts of a total of 60 people found 3 cases . Close contacts of the investigation and concentrated isolation found in 3 cases, close contacts 59 were not found in cases of swine flu H1N1. Conclusion Investigation of close contacts and isolation of medical observation are effective measures for timely detection of recurrence cases and prevention of further spread and spread of the outbreak. The different ways of finding cases affect the outcome of close contacts.