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本文建立了测定麦滋林-S颗粒在人体中的血药浓度的高效液相色谱法,对7名健康志愿受试者和3名慢性胃炎患者进行了药代动力学研究,用计算机McpKp程序计算药代动力学参数并拟合了房室模型,以麦滋林-S溶液剂为对照制剂,麦滋林-S颗粒的相对生物利用度为94.12％。
In this paper, a high performance liquid chromatography (HPLC) method was established for the determination of the concentration of Melzin-S in human body. The pharmacokinetics of seven healthy volunteers and three chronic gastritis patients were studied. The computer McpKp program Pharmacokinetic parameters were calculated and the atrioventricular model was fitted. The relative bioavailability of mezlocin-S granules was 94.12% with the combination of mezlocin-S solution as control.