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迄今,合成的头孢菌素已达数百种。3位的改变往往影响其药代动力学特性;7位改变则影响抗菌活性,2位羰基对酯化作用和前药的开发有一定作用。 过去十年有很大数量注射用头孢菌素投
To date, hundreds of cephalosporins have been synthesized. 3 changes often affect its pharmacokinetic properties; 7 changes affect the antibacterial activity, 2 carbonyl on esterification and prodrug development has a role. Over the past decade there has been a significant amount of injectable cephalosporins