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肝纤维化是慢性肝炎后期重要的病理改变最终叮导致肝硬化。由于肝纤维化早期可被降解逆转,因此慢性肝纤维化的早期诊断对肝硬化的防治具有重要意义。寻找肝纤维化的血清标志物,为临床提供一种既敏感,又非创伤性的诊断方法已成为目前研究的热点。本文采用放免法对147例肝病患者联合检测血清Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、层粘蛋白(Ln)含量,旨在分析探讨其对肝损伤肝纤维化时的临床诊断价值和意义。 对象和方法 一、对象:肝炎诊断按1990年5月上海病毒性肝炎会议修订标准。正常人组共104例(男65,女39)均为健康体检者,平均年龄37.3岁(21～57岁)。147例患者均是我院的住院病人,急性肝炎(CAH)39例,慢性迁延型肝炎(CPH)54例,慢性活动型肝炎(CAⅡ)29例,肝炎后肝硬化(LC)25例。排除肾脏、结缔
Liver fibrosis is an important pathological change in the late stages of chronic hepatitis that eventually leads to cirrhosis. Because of the early liver fibrosis can be degraded reverse, so the early diagnosis of chronic liver fibrosis is of great significance for the prevention and treatment of cirrhosis. Looking for serum markers of liver fibrosis, providing a sensitive and non-invasive diagnostic method for clinical has become a hot spot in the current research. In this paper, 147 cases of liver disease patients with combined detection of serum type Ⅲ procollagen (PC Ⅲ), hyaluronic acid (HA), laminin (Ln) content by radioimmunoassay, to analyze the clinical diagnosis of hepatic fibrosis Value and meaning. Subjects and methods First, the object: Hepatitis diagnosis according to May 1990 Shanghai virus hepatitis meeting revised standards. The normal group of 104 cases (male 65, female 39) were healthy subjects, the average age of 37.3 years (21 to 57 years). All 147 patients were hospitalized in our hospital. There were 39 cases of acute hepatitis (CAH), 54 cases of chronic protracted hepatitis (CPH), 29 cases of chronic active hepatitis (CA Ⅱ) and 25 cases of posthepatitis cirrhosis (LC). Exclude the kidneys, connectives