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目的:探讨用二甲双胍治疗胰岛素抵抗的多囊卵巢综合征患者疗效(curative effect)及安全性。方法:选择就诊于南华大学附属第二医院妇产科门诊符合条件的28例不孕症患者,将其随机平均两组。两组治疗前各项指标比较,差异均无统计学意义(P>0.05)。两组均在治疗前测促卵泡素(FSH)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)、空腹及餐后胰岛素。A组单用维生素E治疗,100mg/d口服;B组单用二甲双胍治疗,500mg/次,3次/d。观察月经恢复情况,确定怀孕即停药。治疗3个月后复查内分泌,空腹及餐后血胰岛素水平。结果:观察组与对照组治疗前后胰岛素、排卵及妊娠情况相比差异有显著性。结论:二甲双胍在改善多囊卵巢综合征(PCOS)患者胰岛素抵抗的同时,增加了其排卵率及妊娠率。
Objective: To investigate the curative effect and safety of metformin in the treatment of insulin resistance in patients with polycystic ovary syndrome. Methods: 28 cases of infertility patients who met the conditions of Obstetrics and Gynecology Clinic of the Second Affiliated Hospital of Nanhua University were selected and randomly divided into two groups. There was no significant difference between the two groups before treatment (P> 0.05). Both groups tested FSH, LH, T, E2, fasting and postprandial insulin before treatment. Group A treated with vitamin E alone, 100mg / d orally; Group B metformin alone, 500mg / time, 3 times / d. Observation of menstrual recovery, that pregnancy is discontinued. 3 months after treatment review endocrine, fasting and postprandial blood insulin levels. Results: There was significant difference between the observation group and the control group before and after treatment of insulin, ovulation and pregnancy. Conclusion: Metformin improves insulin resistance in patients with PCOS and increases its ovulation rate and pregnancy rate.