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对62例初诊T2DM患者按BMI分为肥胖组和非肥胖组,经胰岛素短期强化治疗后。结果:肥胖组HOMA-IR、合并MS、尿MA增高数大于非肥胖组。而肥胖组有糖尿病家族史病例数低于非肥胖组。经胰岛素短期强化治疗后,两组血糖值、HbA1c、HOMA-β均获得显著改善。HOMA-IR无显著差异。结论:早期使用胰岛素强化治疗有助于β细胞分泌功能、糖代谢的改善,尤其对于初诊肥胖糖尿病患者,更利于胰岛功能的恢复。
62 cases of newly diagnosed T2DM patients were divided into obesity group and non-obese group according to BMI, after short-term intensive insulin therapy. Results: HOMA-IR, MS and urine MA in obesity group were higher than those in non-obese group. The obesity group had a lower prevalence of family history of diabetes than non-obese group. After insulin short-term intensive treatment, the two groups of blood glucose values, HbA1c, HOMA-β were significantly improved. HOMA-IR no significant difference. CONCLUSIONS: Early intensive insulin treatment contributes to the secretion of β cells and the improvement of glucose metabolism, especially for newly diagnosed obese diabetic patients, which is more conducive to the recovery of pancreatic islet function.