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目的探究乳腺癌患者血管内皮生长因子-C(VEGF-C)的表达水平与淋巴结转移及预后的关系。方法选取2013年6月~2014年1月该院收治的61例乳腺癌患者为研究对象,采用免疫组化法对研究对象的肿瘤石蜡切片进行检查,观察并分析VEGF-C在不同病理状态下的表达状态及其与乳腺癌淋巴转移的关系。结果乳腺癌有淋巴结转移患者VEGF-C阳性表达率为75.75%,乳腺癌无淋巴结转移患者VEGF-C阳性率为50.00%。VEGF-C阳性表达率与年龄、肿瘤大小及临床TNM分期无关,差异无统计学意义(P均>0.05),而与患者淋巴结转移有关(P<0.05);相关性分析显示,VEGF-C的阳性表达与乳腺癌淋巴结转移情况呈正相关关系(r=0.267,P=0.037)。结论乳腺癌患者VEGF-C的表达与乳腺癌淋巴转移密切相关,检测早期乳腺癌患者VEGF-C的表达对其预测和治疗乳腺癌淋巴转移具有一定的价值。
Objective To investigate the relationship between the expression of vascular endothelial growth factor-C (VEGF-C) and lymph node metastasis and prognosis in patients with breast cancer. Methods Sixty-one breast cancer patients admitted to our hospital from June 2013 to January 2014 were enrolled in this study. Immunohistochemistry was used to examine the paraffin sections of the tumor. The levels of VEGF-C in different pathological states And its relationship with lymphatic metastasis in breast cancer. Results The positive rate of VEGF-C expression in breast cancer patients with lymph node metastasis was 75.75%. The positive rate of VEGF-C in breast cancer patients without lymph node metastasis was 50.00%. The positive rate of VEGF-C was not related with age, tumor size and TNM staging (P> 0.05), but correlated with lymph node metastasis (P <0.05). Correlation analysis showed that VEGF-C There was a positive correlation between the positive expression and lymph node metastasis in breast cancer (r = 0.267, P = 0.037). Conclusion The expression of VEGF-C in breast cancer patients is closely related to the lymphatic metastasis of breast cancer. Detecting the expression of VEGF-C in early stage breast cancer patients is of value in predicting and predicting lymphatic metastasis of breast cancer.