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目的探讨急性心理应激对不同行为类型人群的血浆血栓素B2(TXB2)及6-酮-前列腺素(6-keto-PGF1a)的影响。方法用A型行为问卷(TABP)对150名大学生自愿者进行测试,筛选出A型行为和B型行为组各24名,再对A型行为和B型行为组随机分为应激组和对照组;应激后用放射免疫法测定其血浆中TXB2及6-Keto-PGF1a的含量。结果心理应激后,实验组及A、B型行为实验组血浆TXB2浓度均升高,与对照组相比差异有显著性(P<0.05);实验组及A、B型行为实验组血浆6-keto-PGF1a浓度均有变化,但差异均无显著性(P>0.05);实验组及B型行为实验组TXB2/6-Keto-PGF1a的比值都明显变大,差异均有显著性(P<0.05)。结论1急性心理应激可导致大学生血浆TXB2升高,TXB2/6-Keto-PGF1a的比值变大,提示应激可能是引起心血管功能改变的关键因素之一;2心理应激对不同行为大学生血浆TXB2及6-Keto-PGF1a浓度的影响不同,该结果可能是揭示特定人格好发心脑血管疾病的机制之一。
Objective To investigate the effects of acute psychological stress on plasma TXB2 and 6-keto-prostaglandin (6-keto-PGF1a) in different behavioral groups. Methods A total of 150 college students volunteers were tested by Type A Behavior Questionnaire (TABP). A type A and B type B groups were screened out. Twenty - four type A and B type B groups were randomly divided into stress group and control group The levels of TXB2 and 6-Keto-PGF1a in plasma were measured by radioimmunoassay after stress. Results After psychological stress, the levels of plasma TXB2 in experimental group and A, B group were higher than those in control group (P <0.05). In experimental group and A, B group, (P> 0.05). The ratios of TXB2 / 6-Keto-PGF1a in experimental group and experimental group B were significantly higher than those in experimental group (P <0.05). Conclusions1 Acute psychological stress can lead to the increase of TXB2 in plasma and the increase of TXB2 / 6-Keto-PGF1a, which suggests that stress may be one of the key factors that cause cardiovascular changes.2 Psychological stress has a negative effect on the behavior of college students with different behaviors The effect of plasma TXB2 and 6-Keto-PGF1a concentration is different, and the result may be one of the mechanisms to reveal the cardiovascular and cerebrovascular diseases with specific personality.