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1978年开始,我们逐年综述了国内新药研制的成果。1978～1979两年中,每年通过临床鉴定的单一药物分别为32,31种。其中仿制品种占54%,大部分为化学合成药物;创制性药物占46%,大都来源于中草药。1980年通过临床鉴定的药物,经初步汇集为34种,其中属创制性的计17种,包括复方中药3种。仿制的也是17种。另有两种,一为老药的新用途,一为植物来源药的合成品。抗微生物感染药物三氮唑核苷(ribavirin)(1980,11)是近年发展的一个重要的广谱抗病毒药物。体外组织培养及动物试验中,对许多种 DNA 病毒和 RNA 病毒均有抑制作用。其作用机理主要是抑制核酸合成,干扰DNA 的合成,从而阻止病毒的复制。国内外都对本品进行了大量的临床研究,结果表明,本品对水痘、麻疹、流感、腮腺炎、眼单疱性角膜炎、疱疹性口腔炎、单纯疱疹、带状疱疹、小儿腺病毒肺炎等等病毒性感染均有显著疗效,不良反应少见,是一个值得重视的抗病毒药物。
Beginning in 1978, we reviewed the achievements of domestic drug development year after year. In 1978 ~ 1979 two years, each year through the clinical identification of a single drug were 32,31 species. Among them, 54% were imitation varieties, most of which were chemically synthesized drugs. Creative drugs accounted for 46%, mostly derived from Chinese herbal medicine. The drugs that passed the clinical examination in 1980 were initially collected into 34 kinds, of which 17 were creative ones, including 3 kinds of traditional Chinese medicines. Imitation is also 17 species. There are two other types, one is the new use of the old drug and the other is the synthetic product of the plant-derived medicine. Ribavirin (1980,11), an anti-microbial infection drug, is an important broad-spectrum antiviral drug that has developed in recent years. In vitro tissue culture and animal experiments, for many kinds of DNA viruses and RNA viruses are inhibited. Its mechanism of action is mainly to inhibit nucleic acid synthesis, interfering with DNA synthesis, thus preventing the virus replication. This product at home and abroad have conducted a large number of clinical studies, the results show that the product of chicken pox, measles, influenza, mumps, herpes simplex keratitis, herpes stomatitis, herpes simplex, herpes zoster, pediatric adenovirus Pneumonia and other viral infections have a significant effect, rare adverse reactions, is worthy of attention antiviral drugs.