自1991年7月至1992年4月,广东省肿瘤化疗协作组采用含鮀滨阿霉素的各种联合化疗方案共治疗恶性肿瘤994例,总有效率51.6％,完全缓解率17％。主要毒性反应为轻度或中度的消化道反应,白细胞下降和脱发;绝大多数患者均可以耐受。多数病例使用2—4疗程化疗后未见明显心脏毒性。本组治疗经验表明鮀滨阿霉素疗效和毒性似与过去使用的进口阿霉素无明显差异。 From July 1991 to April 1992, the Guangdong Provincial Cancer Chemotherapy Group used a variety of combined chemotherapy regimens that included silyridin doxorubicin to treat 994 cases of malignant tumors with a total effective rate of 51.6% and a complete remission rate of 17%. The main toxicities were mild or moderate gastrointestinal reactions, leukopenia, and hair loss; most patients were tolerated. In most cases, no obvious cardiotoxicity was observed after 2-4 cycles of chemotherapy. The treatment experience in this group showed that the efficacy and toxicity of SBMI did not differ significantly from those of imported adriamycin used in the past.