多系统器官衰竭(MSOF)已成为严重感染、创伤或大手术后的主要死亡原因,虽极力救治,病死率仍高达40%～60%。重新探讨其发病机制,设计新的治疗方案已迫的眉睫。研究MSOF的重要发现是:在全身炎症反应综合征(SIRS)中微血管内有微血栓(血小板、纤维蛋白)形成,即弥散性血管内凝血(DIC)的存在。炎症激活凝血系统,凝血因子加重炎症与抗凝蛋白抑制 MSOF has become the leading cause of death after severe infection, trauma or major surgery. Despite intensive treatment, the case fatality rate remains as high as 40% -60%. To re-explore the pathogenesis, the design of new treatment options is imminent. An important finding in the study of MSOF is the presence of microthrombi (platelet, fibrin) formation in the microvessels in the systemic inflammatory response syndrome (SIRS), the presence of disseminated intravascular coagulation (DIC). Inflammation activates the coagulation system, clotting factors aggravate inflammation and inhibition of anticoagulants