【摘 要】
：
The installation of azoles via C-H/N-H cross-coupling is significantly underdeveloped,particularly in benzylic C-H azolation due to the requirement for external chemical oxidants and the challenge in controlling the site-and chemo-selectivity.Herein,a lat
【机 构】
：
Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respirato
论文部分内容阅读
The installation of azoles via C-H/N-H cross-coupling is significantly underdeveloped,particularly in benzylic C-H azolation due to the requirement for external chemical oxidants and the challenge in controlling the site-and chemo-selectivity.Herein,a late-stage azolation of benzylic C-H bonds enabled by electrooxidation is described,which proceeds in an undivided cell under mild,catalyst-and chemical-oxidant-free reaction conditions.The strategy empowers the C-H azolation on primary,secondary,and even challenging tertiary benzylic positions selectively.The remarkable synthetic utility of our approach is highlighted by its easy scalability without overoxidation of products and ample scope with valuable functional groups.The approach can be directly used to install benzyl and azole motifs on highly functionalized drug molecules.
其他文献
In this paper,we consider the problem of the nonnegative scalar curvature(NNSC)-cobordism of Bartnik data(Σn-11,γ1,Hi)and(Σn-12,γ2,H2).We prove that given two metrics γ1 and γ2 on Sn-1(3≤n≤7)with H1 fixed,then(Sn-1,γ1,H1)and(Sn-1,γ2,H2)admit no NNSC-cobor
The Christoffel problem is equivalent to the existence of convex solutions to the Laplace equation on the unit sphere Sn.Necessary and sufficient conditions have been found by Firey(1967)and Berg(1969),by using the Green function of the Laplacian on the s
Motivated by our previous work on Hodge-index type theorems,we give a form of mixed Hodge-Riemann bilinear relation by using the notion of m-positivity,whose proof is an adaptation of the works of Timorin(1998)and Dinh and Nguyên(2006).This mixed Hodge-Ri
Motivated by the study of coupled K?hler-Einstein metrics by Hultgren and Witt Nystr?m(2018)and coupled K(a)hler-Ricci solitons by Hultgren(2017),we study in this paper coupled Sasaki-Einstein metrics and coupled Sasaki-Ricci solitons.We first show an iso
This study proposes two different methods of photocatalytic-controlled and visible light-induced selective oxidation of pyr-idiniums with air as the terminal oxidant.The key to these transformations is to choose the appropriate light source and photocatal
Excessive consumption of fossil fuels has led to an un-precedented increase of carbon dioxide (CO2) emission and triggered a series of environment issues and energy crisis [1].Converting CO2 into hydrocarbon fuels has been regarded as an effective approac
The orthogonal Latin hypercube design and its relaxation,and column-orthogonal design,are two kinds of orthogonal designs for computer experiments.However,they usually do not achieve maximum stratifi-cations in multi-dimensional margins.In this paper,we p
The solid electrolyte interphase (SEI) has caught considerable attention as a pivotal factor affecting lithium (Li) metal battery performances.However,the understanding of the interfacial evolution and properties of the on-site formed SEI shells on Li dep
The classical critical Trudinger-Moser inequality in R2 under the constraint ∫R2(| ▽u|2+|u|2)dx≤1 was established through the technique of blow-up analysis or the rearrangement-free argument:for any τ＞0,it holds that sup u∈H1(R2)∫R2(τ|u|2+|Vu|2)dx≤1 ∫R2(e
Methane (CH4) is the main component of natural gas,causing severe greenhouse effect [1].To date,about 90％ of CH4 is burned into carbon dioxide (CO2) and released into the atmosphere through various ways,resulting in not only a waste of resource but also a