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目的:建立测定盐酸恩丹西酮乳酸羟基乙酸共聚物微球含量的方法。方法:采用二氯甲烷溶解微球后,再以水提取主药,用紫外分光光度法测定药物的含量。结果:盐酸恩丹西酮在2-20μg·ml-1的范围内,浓度与吸收度的线性关系良好, 平均回收率为98．76％±0．64％,RSD为1．82％。结论:该方法操作简单、可靠,可用于快速测定微球中药物的含量。
Objective: To establish a method for the determination of ondansetron hydrochloride lactic acid glycolic acid copolymer microspheres content. Methods: After dissolving the microspheres with methylene chloride, the main drug was extracted with water and the content of the drug was determined by UV spectrophotometry. RESULTS: Ondansetron hydrochloride had a good linear relationship between concentration and absorbance in the range of 2-20 μg · ml-1 with an average recovery of 98.76% ± 0.64% and a RSD of 1.82%. Conclusion: The method is simple and reliable, and can be used for rapid determination of drug content in microspheres.