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本实验研究了消炎痛、芬布芬、酮布洛芬、萘普生及地塞米松对小白鼠腹腔渗出液白细胞数量和巨噬细胞吞噬功能的影响。在治疗剂量下,消炎痛和酮布洛芬均使渗出液中白细胞数量显著地减少(P<0.01);芬布芬和萘普生虽有减少,但无统计学意义;地塞米松亦有效地使白细胞减少(P<0.05)。所试药物均显著地抑制巨噬细胞的吞噬功能,降低吞噬率(P<0.01)和吞噬指数(P<0.01)。此外还用放射免疫测定法测定了细胞内cAMP含量的变化,芬布芬和酮布洛芬显著地增加细胞内cAMP含量(P<0.05)。这提示其抗炎作用可能部分通过细胞内cAMP含量的升高而介导的。
In this study, the effects of indomethacin, fenbufen, ketoprofen, naproxen and dexamethasone on white blood cell count and macrophage phagocytosis in mice peritoneal exudate were studied. Both indomethacin and ketoprofen decreased the number of leukocytes in the exudate significantly (P <0.01) at the therapeutic dose, while there was no significant difference between fenbufen and naproxen Effective leukopenia (P <0.05). The tested drugs all significantly inhibited the phagocytosis of macrophages, reduced phagocytosis rate (P <0.01) and phagocytic index (P <0.01). In addition, radioimmunoassay was used to determine the changes of intracellular cAMP levels. Fenbufen and ketoprofen significantly increased intracellular cAMP levels (P <0.05). This suggests that its anti-inflammatory effects may be partly mediated by elevated intracellular cAMP levels.