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目的 观察小剂量静脉应用地尔硫 艹卓 治疗对伴舒张功能障碍充血性心力衰竭 (CHF)患者的疗效。方法 严重CHF患者 114例 ,随机分为A、B两组。A组 5 8例 ,静脉应用地尔硫 艹卓 ;B组 5 6例 ,口服卡托普利 (商品名 :开博通 )。观察期间两组均给地高辛、利尿剂治疗。治疗前后评价心功能 (NYHA) ,监测血浆肾素活性 (PRA)及血管紧张素Ⅱ (A Ⅱ ) ,多普勒超声心动图评价左心室功能。结果 A组治疗后平均NYHA改善 (0 .74± 0 .32 )级 (P <0 .0 1) ,B组改善 (0 .36± 0 .11)级 (P <0 .0 5 ) ,两组比较差异有统计学意义 (P <0 .0 5 )。两组舒张功能、收缩功能、泵功能较治疗前均有显著改善 (P <0 .0 1) ,治疗后两组舒张功能比较差异有统计学意义 (P <0 .0 5 )。A组血浆PRA治疗后显著降低 (P <0 .0 1) ,A组与B组比较差异有统计学意义 (P <0 .0 1)。结论 舒张功能障碍CHF患者静脉应用地尔硫 艹卓 加洋地黄、利尿剂治疗 ,是一种安全、有效的方法
Objective To observe the therapeutic effect of low dose intravenous diltiazem on patients with diastolic dysfunction and congestive heart failure (CHF). Methods Severe CHF patients 114 cases, were randomly divided into A, B two groups. A group of 58 cases, intravenous Diltiazem; B group 56 cases, oral captopril (brand name: open Broadcom). During the observation period, both groups were treated with digoxin and diuretics. Cardiac function (NYHA) was assessed before and after treatment, plasma renin activity (PRA) and angiotensin Ⅱ (A Ⅱ) were monitored, and left ventricular function was evaluated by Doppler echocardiography. Results After treatment, the average NYHA improved (0.74 ± 0.32), the improvement in group B (0.36 ± 0.11) (P <0.05) The difference was statistically significant (P <0. 05). The diastolic function, systolic function and pump function in both groups were significantly improved (P <0.01). The diastolic function of the two groups after treatment was significantly different (P <0.05). The plasma PRA level in group A was significantly lower after treatment (P <0.01), and the difference between group A and group B was statistically significant (P <0.01). Conclusion Diastolic dysfunction in patients with intravenous Diltiazem Zhuo plus digitalis, diuretics, is a safe and effective method