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“814”(茶叶提取物)是一种新型的高效杀精剂。其杀精效果优于我国的ZDZ(猪胆粉)。电镜观察证明“814”可引起精子结构严重破坏,主要损害精子的重要细胞器顶体和线粒体。生化测定表明“814”处理后精子被破坏,释出乳酸脱氢酶、破性磷酸酶、谷草转氨酶和胆固醇。“814”的LD_(50)高于国外新型避孕药Tritonx—100,3％浓度对小鼠阴道无刺激作用,1％或更低浓度对家兔和豚鼠眼结膜和皮下无刺激作用,3％浓度无溶血作用,但可使血浆蛋白和糖浆迅速凝固.十三名妇女试用60mg“814”后,阴道pH仍在正常范围.
“814” (tea extract) is a new type of highly effective spermicide. Its spermicidal effect is better than ZDZ (porcine powder) in our country. Electron microscopy shows that “814” can cause serious damage to the structure of sperm, mainly damaging the sperm acrosome and mitochondria. Biochemical assays showed that spermatozoa were destroyed after 814 treatment, releasing lactate dehydrogenase, phosphatase, aspartate aminotransferase and cholesterol. LD_ (50) of “814” was higher than that of Tritonx-100, a novel foreign contraceptive pill, with no stimulation of the vagina in mice. No irritation was observed in conjunctiva and subcutaneous of rabbits and guinea pigs at a concentration of 1% Concentration without hemolysis, but rapid plasma protein and syrup coagulation. Thirteen women tried 60mg “814”, the vaginal pH is still in the normal range.