扑热息痛(paracetamol)是目前应用最广泛的药物之一,大剂量用药,既有肾毒性又有肝毒性,此毒性是通过游离基的作用。近来,人们想象要是氨基甙类抗生素的耳毒性也是由于它们游离基的作用,与此相似、提示扑热息痛亦应有耳毒性,但文献中尚无此报道。为此,作者们进行了下述试验,目的是验证扑热息痛有无耳毒性并确定它是否加重袢利尿剂的耳毒性。用杂色豚鼠,记录电极安放于圆窗,纯音刺激,目测复合动作电位(CAP)确定听阈,观察0.2%扑热息痛-黄蓍胶混悬液(500mg/kg)、2%黄蓍胶水悬液、12%扑热息痛Tween 80溶液(1000mg/kg)和只注入丁ween 80等量溶液的短期和长期影响。结果,短期影响:腹腔内注入速尿(100mg/ Paracetamol (paracetamol) is currently one of the most widely used drugs, high-dose medication, both nephrotoxicity and hepatotoxicity, this toxicity is through the role of free radicals. Recently, people think if aminoglycoside ototoxicity is also due to their role as free radicals, similar to this, suggesting that paracetamol ototoxicity should be, but not yet reported in the literature. For this reason, the authors conducted the following tests to verify whether there is ototoxicity in paracetamol and whether it aggravated ototoxicity of diuretics. With variegated guinea pigs, the recording electrodes were placed on round windows and pure tone stimuli were taken. The auditory threshold was determined by visual acuity of compound action potential (CAP), and 0.2% paracetamol-tragacanth suspension (500 mg / kg) Short-term and long-term effects of 12% paracetamol Tween 80 solution (1000 mg / kg) and an equal volume of solution injected only with Ding ween 80. Short-term effects: Intraperitoneal injection of furosemide (100 mg /