转化生长因子β(TGF-β)是一组调节细胞生长和分化的细胞因子。多数肿瘤细胞可产生TGF-β,其对免疫功能的影响为:①通过影响IL-2R、细胞周期Rb蛋白、c-myc表达、诱导淋巴细胞凋亡等机制,抑制T细胞增殖;②抑制NK、LAK、CTL杀伤活性;⑧影响巨噬细胞的功能。抗TGF-β单抗、反义基因、TGF-β拮抗剂和信号传导阻断剂逆转TGF-β的免疫抑制作用,可作为抗肿瘤治疗新策略。 Transforming growth factor beta (TGF-β) is a group of cytokines that regulate cell growth and differentiation. The majority of tumor cells can produce TGF-β, and its effects on immune function are as follows: 1 inhibit T cell proliferation by affecting IL-2R, cell cycle Rb protein, c-myc expression, inducing apoptosis of lymphocytes, etc.; 2 inhibiting NK , LAK, CTL killing activity; 8 affect macrophage function. Anti-TGF-β monoclonal antibodies, antisense genes, TGF-β antagonists, and signal transduction inhibitors reverse the immunosuppressive effects of TGF-β, and can be used as new strategies for anti-tumor therapy.