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目的探讨以血浆白蛋白值作为肝素治疗肾病综合征指征的可行性。方法根据血浆白蛋白值分成两组 ,并设血白蛋白值正常对照组 ,肝素治疗前后分别测凝血时间、KPTT、BPC,观察静脉穿刺点压迫出血时间及皮肤、粘膜、上下消化道出血情况。结果随着血浆白蛋白值的降低。凝血时间、KPTT越来越短 (P均 <0 .0 1) ,BPC越来越多 (P<0 .0 1)。肝素治疗后 ,血浆白蛋白值越低 ,凝血时间、KPTT延长越短。在安全范围内 ,无出血情况。结论血浆白蛋白值作为肝素治疗肾病综合征指征可行、安全。
Objective To investigate the feasibility of using plasma albumin as a marker for the treatment of nephrotic syndrome. Methods Plasma albumin was divided into two groups according to the serum albumin value. The blood coagulation time, KPTT and BPC were measured before and after heparin treatment. The hemorrhage time of the venous puncture point and the hemorrhage of the skin, mucous membrane and upper and lower gastrointestinal tract were observed. The result is a decrease in plasma albumin values. Clotting time, KPTT shorter and shorter (P <0.01), BPC more and more (P <0.01). After heparin therapy, the lower the plasma albumin value, the shorter the clotting time and the KPTT extension. In the safe range, no bleeding situation. Conclusion Plasma albumin value as a heparin treatment of nephrotic syndrome indications feasible and safe.