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目的 :为了探讨慢性肾功能不全患者血层粘连蛋白 (LN)和α1-微球蛋白 (α1-MG)含量的变化及临床意义。方法 :79例慢性肾功能不全患者以血肌酐 (Cr)水平分为氮质血症组和尿毒症组 ,用放免分析法对全部患者血清LN和α1-MG进行检测。结果 :氮质血症组与尿毒症组LN和α1-MG分别与对照组相比均有显著性差异 (P <0 .0 2 ) ,尿毒症组血清α1-MG水平明显高于氮质血症组 (P <0 .0 1) ,尿毒症组与氮质血症组血清LN水平无差异 (P >0 .0 5 )。结论 :血中LN和α1-MG水平测定可作为肾功能不全的实验室指标之一
Objective: To investigate the changes and clinical significance of laminin (LN) and α1-microglobulin (α1-MG) in patients with chronic renal failure. Methods: Seventy-nine patients with chronic renal failure were divided into azotemia group and uremia group by serum creatinine (Cr) level. Serum LN and α1-MG were detected by radioimmunoassay. Results: LN and α1-MG in azotemia group and uremia group were significantly different from those in control group (P <0. 02), serum α1-MG level in uremia group was significantly higher than that in azotemia group There was no significant difference in serum LN between uremia group and azotemia group (P> 0.05). Conclusion: The determination of LN and α1-MG levels in blood can be used as a laboratory index of renal insufficiency