近日,一项刊登在国际杂志Science Immunology上的研究报告中,来自南卡罗莱纳医科大学的研究人员通过研究发现,血小板或许能够通过抑制T细胞的功能来帮助癌症隐藏免于被免疫系统发现;在广泛的临床前实验中,当研究者添加了诸如阿司匹林等抗血小板药物时,潜在的T细胞疗法或许就能够成功增强机体抵御黑色素瘤的免疫力。研究者Zihai Li表示,血小板能够释放一些名为TGF-beta的特殊分子来抑制抵御癌症的T细胞的活性,很多年以来,研究者认为TGF-beta分子在癌症生长过程中扮演着关键角色。然而本文研究或许是第一个特例,研究者发现大部分TGF-beta分子都处于无活性状态,血小板表面有 In a recent study published in the journal Science Immunology, researchers from South Carolina Medical University found that platelets may help hide cancer from being detected by the immune system by inhibiting the function of T cells. In a wide range of preclinical experiments, when researchers added antiplatelet drugs such as aspirin, potential T cell therapy might be able to successfully boost the body’s immune system against melanoma. Researchers Zihai Li said that platelets release specific molecules called TGF-beta to suppress cancer-fighting T-cell activity, and for many years researchers have suggested that TGF-beta molecules play a key role in cancer growth. However, this study may be the first special case, the researchers found that most of the TGF-beta molecules are inactive, platelet surface