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目的:为推动世界卫生组织三阶梯癌症止痛计划的广泛实施,本文初步考察酚咖片(加合百服咛)治疗癌症疼痛的有效性及安全性。方法:从1997-06/1999-05利用多中心研究方法,应用酚咖片治疗126例癌痛患者(轻、中、重度癌痛者分别为36、60、30例)。结果:酚咖片对轻、中、重度癌痛的总有效率分别为89%、50%、33%;起效时间分别为(24±6)、(39±18)、(45±26)min,缓解时间分别为(6.5±1.7)、(4.8±1.5)、(3.1±1.1)h,4h后酚咖片追加率分别为14%,75%及100%。副反应恶心呕吐、头晕、过敏反应发生率分别为5.6%、2.4%及0.8%,1例(0.8%)可能出现药物耐受现象。结论:临床试验初步结果表明,酚咖片治疗癌痛的适应证是轻度癌痛,对部分中度癌痛患者也有较好的效果。由于病例数偏少等原因,尚需进一步验证治疗癌痛患者的有效性及安全性。
OBJECTIVE: To promote the widespread implementation of the World Health Organization’s Three-Step Cancer Pain Relief Plan, this paper examines the efficacy and safety of phenolic coffee tablets in the treatment of cancer pain. Methods: From 1997-06 / 1999-05, 126 patients with cancer pain were treated with phenocarpide (36, 60 and 30 patients with mild, moderate and severe cancer pain respectively) by multi-center research method. Results: The total effective rate of phenol-caffeine tablet for light, moderate and severe cancer pain was 89%, 50% and 33% respectively. The onset time was (24 ± 6), (39 ± 18) and (45 ± 26) min, and the time of remission were (6.5 ± 1.7), (4.8 ± 1.5) and (3.1 ± 1.1) h, respectively. The recoveries of phenolic coffee tablets after 4 hours were 14%, 75% and 100%, respectively. Side effects of nausea and vomiting, dizziness, allergic reactions were 5.6%, 2.4% and 0.8%, 1 case (0.8%) may be drug resistance phenomenon. Conclusion: The preliminary results of clinical trials show that the indications for the treatment of cancer pain with phenolic coffee tablets are mild cancer pain, and also have good effect on some patients with moderate cancer pain. Due to the small number of cases and other reasons, the effectiveness and safety of patients with cancer pain need to be further verified.