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[目的]探讨高频电波刀电圈切除术(LEEP)与阴道镜下多点活检组织学检查对宫颈疾病诊断的临床价值。[方法]选择经阴道镜宫颈活检病理组织学检查诊断为宫颈上皮内瘤变(CIN)的患者,采用LEEP手术诊断治疗908例。切除宫颈病变组织,手术标本再次行病理组织学检查。[结果]908例中CIN级别不同程度升高者164例(18.1%),其中CINⅠ级67例,LEEP术后病理为CINⅡ级41例,CINⅢ级23例,原位癌2例,腺癌1例;CINⅡ级45例LEEP术后病理为CINⅢ级30例,原位癌10例,早期浸润癌4例,鳞癌1例;CINⅢ级52例LEEP术后病理为原位癌38例,早期浸润癌10例,鳞癌4例。[结论]阴道镜下多点活检有一定的假阴性率,LEEP手术可提供完整的病理标本,对宫颈癌的早期诊断治疗有较大的应用价值。
[Objective] To investigate the clinical value of LEEP and colposcopy biopsy histology in the diagnosis of cervical diseases. [Method] The patients diagnosed as cervical intraepithelial neoplasia (CIN) by colposcopic cervical biopsy pathology were selected, and 908 cases were diagnosed and treated by LEEP. Cervical lesions were removed and the surgical specimens were examined histopathologically again. [Results] There were 164 cases (18.1%) of the 908 cases with varying degrees of CIN grade. Among them, 67 cases were CINⅠ, 41 cases were CINⅡ, 23 cases were CINⅢ, 2 cases were in situ carcinoma, In CINⅡ, 45 cases of LEEP were pathologically classified into 30 cases of CIN Ⅲ grade, 10 cases of carcinoma in situ, 4 cases of early invasive carcinoma and 1 case of squamous cell carcinoma. Fifty-two cases of CINⅢ grade LEEP pathologically were in situ carcinoma of 38 cases, 10 cases of cancer, 4 cases of squamous cell carcinoma. [Conclusion] The multi-point biopsy under colposcopy has a certain false-negative rate. LEEP can provide a complete pathological specimen, which has great value in the early diagnosis and treatment of cervical cancer.