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英国研究人员新进行的一个12周的小样本研究显示,阻断肿瘤坏死因子(TNF)α能有效治疗重症激素依赖性哮喘。17例曾吸入最大剂量皮质激素仍有症状的严重哮喘患者加用重组人TNF受体融合蛋白 (etanercept)每周2次,共12周。结果显示,哮喘控制调查问卷积分值由平均26降到11,早晨和晚上的基础FEV1、FVC与PEF得到改善,支气管的高敏性明显降低。除1例外,其他患者都能停用β2激动剂。但
A new 12-week small sample study by British researchers showed that blocking tumor necrosis factor (TNF) alpha was effective in treating severe hormone-dependent asthma. Seventeen patients with severe asthma who had inhaled the greatest dose of corticosteroids and had symptoms were treated with recombinant human TNF receptor fusion protein (etanercept) twice weekly for 12 weeks. The results showed that the asthma control questionnaire score decreased from an average of 26 to 11, morning and evening basal FEV1, FVC and PEF were improved, bronchial hypersensitivity was significantly reduced. All but one of the patients stopped using beta 2 agonists. but