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目的观测不同时间左心室注射地尔硫对大鼠顿抑心肌功能的影响。方法 Wistar雄性大鼠25只,随机分为5组,假手术组(A组)、顿抑心肌组(B组)、缺血期注射地尔硫组(C组)、再灌注早期注射地尔硫组(D组),再灌注晚期注射地尔硫组(E组),每组5只,观察心率(HR)、左心室收缩末期压(LVESP)、左心室舒张末期压(LVEDP)、左心室内压最大上升速率及最大下降速率(±dp/dt_(max))的变化。结果与A组大鼠比较,除C组再灌注30、60、90、120 min,D组再灌注60、90、120 min时,其他各组在缺血及再灌注后均出现HR增快,LVESP、LVEDP、±dp/dt_(max)降低(P<0.05);C组再灌注30 min、D组再灌注90 min时HR、LVESP、LVEDP、±dp/dt_(max)已恢复至术前水平。与B组大鼠比较,C组再灌注15、30、60、90、120 min,D组再灌注90、120 min HR下降,LVESP、LVEDP、±dp/dt_(max)明显改善(P<0.05)。结论在缺血和再灌注早期左心室注射地尔硫可促进顿抑心肌功能的恢复,而再灌注晚期应用则无明显作用。
Objective To observe the effect of diltiazem administered by left ventricular injection at different times on the function of stunned myocardium in rats. Methods Twenty-five Wistar male rats were randomly divided into 5 groups: sham-operation group (group A), stunned myocardium group (group B), Diltiazem group (group C) during ischemia and early reperfusion (Group D), and diltiazem group (group E) after reperfusion. Five rabbits in each group were observed for heart rate (HR), left ventricular end-systolic pressure (LVESP), left ventricular end-diastolic pressure ), The maximum rate of left ventricular pressure rise and the maximum rate of decline (± dp / dt_ (max)). Results Compared with group A, the HR of all the other groups increased significantly after ischemia and reperfusion except for 30, 60, 90 and 120 min of reperfusion in group C, 60, 90 and 120 min of reperfusion in group D, LVESP, LVEDP and ± dp / dt max decreased (P <0.05). HR, LVESP, LVEDP, ± dp / dt max of group C reperfused to 30 min after reperfusion, Level. Compared with group B, the HR of group C was significantly decreased at 15, 30, 60, 90, 120 min after reperfusion and 90, 120 min after reperfusion in group D (P <0.05 ). Conclusion In the early stage of ischemia and reperfusion, diltiazem in the left ventricle can promote the recovery of myocardial function, while the late application of reperfusion has no obvious effect.