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动态测定了常压间断低氧大鼠全血和肺组织谷胱甘肽过氧化物酶(GSH-PX)活性及还原型谷胱甘肽(GSH)含量。结果发现随低氧时间延长,肺动脉压逐渐升高的过程中有全血及肺组织GSH-PX活性及GSH含量的显著降低。维生素E和山莨菪碱有部分保护作用。提示间断低氧过程中活性氧自由基生成增多,消耗了较多的抗氧化酶(剂)。氧自由基生成增多可能在其肺动脉高压的发生中起一定作用。
The levels of glutathione peroxidase (GSH-PX) and glutathione (GSH) in whole blood and lung tissue of rats with hypobaric hypoxia were measured dynamically. The results showed that with the extension of hypoxia, pulmonary arterial pressure gradually increased in whole blood and lung tissue GSH-PX activity and GSH content was significantly reduced. Vitamin E and anisodamine have some protective effects. Tip intermittent hypoxia generated reactive oxygen species increased production, consume more antioxidant enzymes (agents). Increased production of oxygen free radicals may play a role in the occurrence of pulmonary hypertension.