AIM:To investigate the potential benef it of Fujinon in-telligent chromo endoscopy(FICE)-assisted small bowel capsule endoscopy(SBCE)for detection and character-ization of small bowel lesions in patients with obscure gastroenterology bleeding(OGIB).METHODS:The SBCE examinations(Pillcam SB2,Giv-en Imaging Ltd)were retrospectively analyzed by two GI fellows(observers)with and without FICE enhance-ment.Randomization was such that a fellow did not assess the same examination with and without FICE enhancement.The senior consultant described f indings as P0,P1 and P2 lesions(non-pathological,intermedi-ate bleed potential,high bleed potential),which were considered as reference f indings.Main outcome mea-surements:Inter-observer correlation was calculated using kappa statistics.Sensitivity and specif icity for P2 lesions was calculated for FICE and white light SBCE.RESULTS:In 60 patients,the intra-class kappa cor-relations between the observers and reference f indings were 0.88 and 0.92(P2),0.61 and 0.79(P1),for SBCE using FICE and white light,respectively.Overall 157 le-sions were diagnosed using FICE as compared to 114 with white light SBCE(P = 0.15).For P2 lesions,the sensitivity was 94% vs 97% and specif icity was 95% vs 96% for FICE and white light,respectively.Five(P2 le-sions)out of 55 arterio-venous malformations could be better characterized by FICE as compared to white light SBCE.Significantly more P0 lesions were diagnosed when FICE was used as compared to white light(39 vs 8,P < 0.001).CONCLUSION:FICE was not better than white light for diagnosing and characterizing signif icant lesions on SBCE for OGIB.FICE detected signif icantly more non-pathological lesions.Nevertheless,some vascular le-sions could be more accurately characterized with FICE as compared to white light SBCE. AIM: To investigate the potential benefits of of Fujinon in-telligent chromo endoscopy (FICE) -assisted small bowel capsule endoscopy (SBCE) for detection and character-ization of small bowel lesions in patients with obscure gastroenterology bleeding (OGIB). METHODS: The SBCE examinations (Pillcam SB2, Giv-en Imaging Ltd) were retrospectively analyzed by two GI fellows (observers) with and without FICE enhance ment. Randomization was such that a fellow did not assess the same examination with and without FICE enhancement. consultants described fdings as P0, P1 and P2 lesions (non-pathological, intermediary ate bleed potential, high bleed potential), which were considered as reference f indings. Main outcome mea-surements: Inter-observer correlation was calculated using kappa statistics . Sensitivity and specif icity for P2 lesions was calculated for FICE and white light SBCE. RESULTS: In 60 patients, the intra-class kappa cor- relations between the observers and reference f indings were 0.88 and 0.92 (P2), 0 .62 and 0.79 (P1) for SBCE using FICE and white light, respectively. Overall 157 le-sions were diagnosed using FICE as compared to 114 with white light SBCE (P = 0.15) vs 97% and 96% for 96% for FICE and white light, respectively. FIVE (P2 le-sions) out of 55 arterio-venous malformations could be better characterized by FICE as compared to white light SBCE. lesions were diagnosed when FICE was used as compared to white light (39 vs 8, P <0.001) .CONCLUSION: FICE was not better than white light for diagnosed and characterizing signif icant lesions on SBCE for OGIB. FICE detected signif icantly more non- pathological lesions. promising, some vascular le-sions could be more fairly characterized with FICE as compared to white light SBCE.