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实验观察羟基喹哌(IIPQ)及其磷酸盐(HPQP)的抗疟活性。二药对plasmodium berghei的正常株的ED50低于磷酸氯喹(CQP)的ED50,对抗氯喹株感染的小鼠也有高度的抑制疗效,与CQP仅有轻度的交叉抗性。对P.Cynomolgi感染的猴也有显著的抑制性疗效。用不同剂量和疗程的HPQP和CQP平
The anti-malarial activity of hydroxyquinoline (IIPQ) and its phosphate (HPQP) was experimentally observed. The ED50 of the two drugs against the normal strain of plasmodium berghei is lower than the ED50 of chloroquine phosphate (CQP), and also has a highly inhibitory effect against chloroquine infected mice, with only mild cross-resistance to CQP. P.Cynomolgi infected monkeys also have significant inhibitory effect. With different doses and courses of HPQP and CQP level