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目的了解宁波地区育龄期妇女弓形虫抗体阳性率,探索易感因素,为防治弓形虫感染提供依据。方法采用酶联免疫法和间接血凝法检测育龄期妇女弓形虫血清抗体,对抗体阳性者进行流行病学调查和诊治分析。结果宁波地区680名育龄期妇女弓形虫抗体阳性率为6.18%。阳性感染者均有易感因素,饲养宠物,爱吃半生食物、砧板生熟不分和从事养殖供应肉类分别占抗体阳性者的57.14%、26.19%和16.67%。乙酰螺旋霉素治疗弓形虫,抗体滴度1∶64阳性者未有升高、抗体滴度1∶256阳性者下降至1∶64,肝功能均有好转,且无严重不良反应。结论宁波地区育龄期妇女中弓形虫阳性者占有一定比例,应加强育龄期妇女弓形虫病健康教育、血清学检测、及时治疗抗体阳性者。
Objective To understand the positive rate of Toxoplasma gondii antibody in women of childbearing age in Ningbo and explore the predisposing factors for the prevention and treatment of Toxoplasma gondii infection. Methods Serum antibodies against Toxoplasma gondii in women of childbearing age were detected by enzyme-linked immunosorbent assay (ELISA) and indirect hemagglutination test, and the epidemiology, diagnosis and treatment of antibody positive were analyzed. Results The positive rate of Toxoplasma gondii antibody in 680 women of childbearing age in Ningbo was 6.18%. Positive infection were susceptible factors, keeping pets, eating half-baked food, raw and cooked chopping board regardless of engaged in farming and meat supply accounted for 57.14%, 26.19% and 16.67% respectively. Acetylspiramycin treatment of Toxoplasma gondii antibody titer 1:64 positive did not increase the antibody titer 1:256 positive decreased to 1:64, liver function improved, and no serious adverse reactions. Conclusion Toxoplasma gondii positive in women of childbearing age in Ningbo occupies a certain proportion, and health education, serological test and serological test of toxoplasmosis should be strengthened in women of childbearing age.