对异种胰岛素的小鼠抗体反应,是受H-2-联免疫反应(Ir)基因控制的。作者以前曾证实预先静脉内注射可溶性胰岛素,能特异地抑制对加弗罗因德氏完全佐剂(CFA)的胰岛素的免疫反应。无反应性在静脉内注射后至少经过4天方可产生,一旦产生,可持续4周或更长时间。无反应性可由 T 细胞而不是 B 细胞的耐受性引起;而且,作者始终未能证实抑制性 T 细胞,在引起这种反应 Mouse antibody responses to xenoins are controlled by the H-2-linked immunoreactivity (Ir) gene. The authors have previously demonstrated that pre-intravenous injection of soluble insulin specifically inhibits the immune response to guanfuridine’s complete adjuvant (CFA) insulin. Anergy can be produced at least 4 days after intravenous injection and, once established, for 4 weeks or longer. Anergy can be caused by the tolerance of T cells rather than B cells; moreover, the authors have consistently failed to demonstrate that suppressor T cells that cause this response