通常药物治疗的剂量范围是指产生疗效与发生不可预知毒性的剂量范围。在肿瘤的化学治疗中,化疗药物治疗的剂量范围十分狭窄。肿瘤的化疗已有半个多世纪的历史,化疗药物的毒性大、安全系数较小,而且在人体代谢和排泄个体差异大,因此可能导致个体间不同的治疗效果。所以有必要根据药物的药物代谢动力学设计个体化的理想给药方案,从而达到最大耐量、取得最大疗效、避免不可耐受的毒 In general, the dose range of drug treatment refers to the dose range in which efficacy and unpredictable toxicity occur. Chemotherapy in the chemotherapy of chemotherapy, the dose range is very narrow. Chemotherapy for tumors has been in the history of more than half a century. Chemotherapy drugs are highly toxic and have a low safety factor. They also have large differences in metabolism and excretion in the human body and may therefore lead to different therapeutic effects among individuals. Therefore, it is necessary to design an individualized ideal dosage regimen according to the pharmacokinetics of the drug so as to achieve the maximum tolerance and achieve maximum curative effect and avoid intolerant toxicity