正常情况下,早幼粒白血病基因与维甲酸受体α基因均存在于正常的细胞中,其表达产物对细胞的生长发育均具有十分重要的调控作用。在绝大多数急性早幼粒细胞白血病发病过程中,由于某种原因引起17号染色体与15号染色体之间产生移位,从而导致早幼粒白血病基因与维甲酸受体α基因融合形成早幼粒细胞白血病-维甲酸受体α融合基因,它与急性早幼粒细胞白血病的发生、发展、诊断、治疗以及预后判断等临床关系十分密切。 Under normal circumstances, promyelocytic leukemia gene and retinoic acid receptor alpha gene are present in normal cells, the expression of the product of the cell growth and development are very important regulatory role. In the vast majority of acute promyelocytic leukemia in the pathogenesis, for some reason caused a shift between chromosome 17 and chromosome 15, resulting in promyelocytic leukemia gene and retinoic acid receptor alpha gene fusion early generation The myeloid leukemia-retinoic acid receptor alpha fusion gene has close clinical relationship with the occurrence, development, diagnosis, treatment and prognosis of acute promyelocytic leukemia.