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目的研究阿托伐他汀联合叶酸、维生素B12对伴高脂血症的脑梗死患者的治疗效果。方法按随机双盲方法将87例伴高脂血症的脑梗死患者分成A、B两组,两组患者同时接受缺血性脑卒中的常规治疗。A组予阿托伐他汀联合叶酸、维生素B12,B组则只给予阿托伐他汀,于入院24h内及治疗10周后分别测定各组血浆LDL-C及Hcy水平,并用MMSE量表评估患者治疗前后认知功能的改变。结果 A组治疗10周后患者的LDL-C及Hcy水平显著降低。B组LDL-L水平降低,但Hcy水平改变不明显。A组MMSE评分的提高明显高于B组(P<0.05)。结论阿托伐他汀联合叶酸、维生素B12可显著降低患者的LDL-C及Hcy水平,且可以明显改善伴高脂血症的脑梗死患者的认知功能。
Objective To study the therapeutic effect of atorvastatin combined with folic acid and vitamin B12 on patients with cerebral infarction with hyperlipidemia. Methods A total of 87 patients with cerebral infarction with hyperlipidemia were divided into two groups according to a randomized double-blind method. Patients in both groups received routine treatment of ischemic stroke at the same time. Atorvastatin combined with folic acid and vitamin B12 in group A and only atorvastatin in group B were measured. Plasma LDL-C and Hcy levels in each group were measured 24h after admission and 10 weeks after treatment, and MMSE was used to evaluate the patients Changes in cognitive function before and after treatment. Results The levels of LDL-C and Hcy in group A were significantly decreased after 10 weeks of treatment. The level of LDL-L decreased in group B, but the level of hcy did not change obviously. MMSE score in group A was significantly higher than that in group B (P <0.05). Conclusions Atorvastatin combined with folic acid and vitamin B12 can significantly reduce the level of LDL-C and Hcy in patients and can significantly improve the cognitive function in patients with cerebral infarction with hyperlipidemia.