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目的：比较尼群地平及卡托普利治疗对自发性高血压大鼠（ＳＨＲ）左心室肥厚及左心室小动脉重构的疗效。方法：选用ＳＨＲ及Ｗｉｓｔａｒ－Ｋｙｏｔｏ大鼠（ＷＫＹ）７２只，随机分成１４周龄的ＳＨＲ１４组和ＷＫＹ１４组，２８周龄的ＳＨＲ尼群地平组（３０ｍｇｋｇ－１／ｄ）和卡托普利组（５０ｍｇｋｇ－１／ｄ），２８周龄的高血压对照组（ＳＨＲ２８组）和正常对照组（ＷＫＹ２８组）。每组１２只。观察指标包括左心室心肌重量与体重比值（ＬＶＭ／ＢＷ），冠状动脉血流量，心肌毛细血管密度（ＰＤ），两种不同管径小动脉管壁面积与腔径比值（Ａ／Ｒ），心肌胶原含量及心肌钙离子浓度。结果：１４周龄的ＳＨＲ已有左心室重构，除左心室肥厚外，心肌毛细血管密度减少（２６４±４２ｖｓ．３７２±７１μｍ／μｍ３，Ｐ＜０．０５），Ａ／Ｒ增加，心肌胶原含量（４．６２±０．８４ｖｓ．３．２７±０．９４ｍｇ／１００ｍｇ干重，Ｐ＜０．０５）及心肌钙离子浓度增加，尼群地平或卡托普利降压治疗１４周后，两组的左心室重构的异常表现均有消退或减轻。结论：尼群地平与卡托普利均能逆转ＳＨＲ左心室及心肌血管重构，在降压程度相同时其逆转效果相似。
AIM: To compare the efficacy of nitrendipine and captopril in the treatment of left ventricular hypertrophy and left ventricular arteriolar remodeling in spontaneously hypertensive rats (SHR). Methods: Seventy-two SHR and Wistar-Kyoto rats (WKY) were randomly divided into two groups: SHR14 group and WKY14 group, 14 weeks old SHR group (30mgkg-1 / d) and captopril group (50mgkg-1 / d), 28-week-old hypertension control group (SHR28 group) and normal control group (WKY28 group). 12 in each group. The indexes included left ventricular weight to body weight ratio (LVM / BW), coronary blood flow, myocardial capillary density (PD), ratio of wall area to lumen diameter (A / R) Collagen content and myocardial calcium concentration. Results: Left ventricular remodeling was found in 14-week-old SHR. In addition to left ventricular hypertrophy, myocardial capillary density decreased (264 ± 42 vs. 372 ± 71 μm / μm3, P <0.05), A / R increased, (4.62 ± 0.84vs.3.27 ± 0.94mg / 100mg dry weight, P <0.05) and the increase of calcium concentration in myocardium. After treatment with nitrendipine or captopril for 14 weeks, Left ventricular remodeling in both groups abnormalities have subsided or reduced. CONCLUSION: Both nitrendipine and captopril can reverse the left ventricular remodeling and myocardial remodeling in SHR. The reversal effects of nitrendipine and captopril are similar when the depressurization degree is the same.