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观察氯沙坦对慢性肾功能不全患者的疗效 ,包括对肾性高血压效果、2 4 h尿蛋白总量改变及内生肌酐清除率的影响。方法 对慢性肾功能不全的患者口服氯沙坦 50 mg/d,疗程6～ 8周 ,并与培哚普利治疗组、硝苯地平治疗组比较。结果 氯沙坦能有效、平稳地降低患者血压 ,降低 2 4 h尿蛋白含量 ,而内生肌酐清除率 ,与治疗前对照虽有升高及疗程后组间对照 ,无明显差异。结论 氯沙坦可以延缓慢性肾功能不全的进展
To observe the effect of losartan on patients with chronic renal failure, including effects on renal hypertension, 24 h urine protein and endogenous creatinine clearance rate. Methods Patients with chronic renal insufficiency were treated with losartan 50 mg / d orally for 6-8 weeks, and compared with those in perindopril and nifedipine groups. Results Losartan can effectively and steadily reduce the blood pressure of patients and reduce the content of urinary protein 24 h. The clearance rate of endogenous creatinine was not significantly different from the control before treatment and after treatment. Conclusion Losartan can delay the progress of chronic renal insufficiency