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目的:研究玉叶解毒颗粒体内外抗甲1型流感病毒(Influenza virus)作用。方法:体内试验检测玉叶解毒颗粒对小鼠感染流感病毒所致肺炎的抑制作用和死亡保护;体外实验通过对狗肾细胞(MDCK)的培养,探讨玉叶解毒颗粒在细胞上对感染流感病毒的抑制作用。结果:玉叶解毒颗粒对小鼠肺内的流感病毒有一定的清除作用,能减轻小鼠肺内的炎性病变,在剂量为15g.kg-1时对小鼠有死亡保护作用,体外实验在125g.L-1时能抑制流感病毒。结论:玉叶解毒颗粒在体内外具有明显的抗流感病毒作用。
Objective: To study the effect of Jade Leaf Detoxification Granules on Influenza virus in vitro and in vivo. Methods: In vivo test to detect the inhibitory effect of Jade Leaf Detoxification Granules on pneumonia caused by influenza virus infection in mice and death protection. In vitro experiments on canine kidney cells (MDCK) Inhibition. Results: Jade Leaf Detoxification particles of influenza virus in mice lungs have a certain role in clearing, can reduce inflammatory lung lesions in mice, the dose of 15g.kg-1 on the death of mice with protective effect, in vitro experiments At 125g.L-1 can inhibit influenza virus. Conclusion: Jade Leaf Detoxification Granule has significant anti-influenza virus effect both in vitro and in vivo.