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从血吸虫病患者的脾脏中提取的血吸虫病特异性免疫核糖核酸(S-iRNA),前文业已初步证明S-iRNA在体外具有传递免疫的功能。iRNA注入机体后,可通过淋巴细胞诱生特异性细胞免疫与体液免疫。Barr等报道疟疾特异性iRNA,具有保护小鼠对柏氏疟原虫致死量的攻击,且使鼠体内疟原虫数显著地低于对照组。恒河猴的实验业已证明,血吸虫病获得性免疫机理是通过细胞免疫与体液免疫的协同作用而发挥效应的。本文试用S-iRNA注入家兔,观察其传递免疫的功能及抵抗血吸
Schistosoma japonicum specific RNA (S-iRNA) extracted from the spleen of schistosomiasis patients has previously been shown to have the function of delivering immunity in vitro. After iRNA is injected into the body, specific cellular and humoral immunity can be induced by lymphocytes. Barr et al. Reported malaria-specific iRNAs that protected mice from a lethal dose of Plasmodium berghei and significantly reduced the number of malaria parasites in mice in the control group. Experiments in rhesus monkeys have demonstrated that the acquired immunological mechanism of schistosomiasis exerts its effect through the synergistic effect of cellular and humoral immunity. In this paper, S-iRNA was injected into rabbits to observe its function of transmitting immunity and resisting blood gas