【摘 要】
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Dear EditorAfter 14-years of development,the first prophylactic vaccine against the Hepatitis E virus (HEV) has been marketed since 2012 (Wu et al.,2012).Howeve
【机 构】
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National institute of diagnostics and vaccine development in infectious diseases, Xiamen University,
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Dear EditorAfter 14-years of development,the first prophylactic vaccine against the Hepatitis E virus (HEV) has been marketed since 2012 (Wu et al.,2012).However,the neutralizing epitopes of HEV are not completely defined.E2s,a protruding homodimer domain of HEV capsid protein,is responsible for interacting with host cells to initiate infection (Li et al.,2009;Li et al.,2005).It was shown that two monoclonal antibodies (mAb),8C11 and 8H3,could neutralize the infectivity of HEV in rhesus,and the two mAbs bind to different neutralizing conformational epitopes on E2s (Zhang et al.,2005).
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