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用ＰＣＲ技术检测了２１例多发性骨髓瘤（ＭＭ）病人外周血或骨髓涂片免疫球蛋白重链基因重排，发现１７例阳性，４例阴性，其中２例为轻链型。外周血免疫球蛋白重链（ＩｇＨ）基因重排的检出率与骨髓涂片的结果基本一致，表明ＩｇＨ基因重排为诊断ＭＭ的最敏感方法之一，可弥补形态学、血清学诊断之不足。
The rearrangement of immunoglobulin heavy chain genes in peripheral blood or bone marrow smears in 21 patients with multiple myeloma (MM) was detected by PCR and was found to be positive in 17 cases and negative in 4 cases, of which 2 cases were light chain type. The detection rate of peripheral blood immunoglobulin heavy chain (IgH) gene rearrangement is basically consistent with the results of bone marrow smears, indicating that IgH gene rearrangement is one of the most sensitive methods for diagnosing MM, which can make up for morphological and serological diagnosis. insufficient.