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目的：探讨人脑胶质瘤组织内微血管数量（ＭＶＣ）和ｎｍ２３基因表达的临床意义．方法：对５４例人脑胶质瘤组织内的ＭＶＣ和ｎｍ２３基因表达采用免疫组化染色进行回顾性研究．结果：ＭＶＣ随胶质瘤的恶性程度及瘤周水肿的严重程度增加而增多，复发组ＭＶＣ明显高于未复发组（Ｐ＜０．０１）．同时发现ｎｍ２３表达阳性强度与人脑胶质瘤的恶性程度及瘤周水肿呈负相关（ｒ分别为－０．４８和－０．５１，Ｐ＜０．０１），复发组ｎｍ２３阳性表达率显著低于未复发组（Ｐ＜０．０５），且瘤组织内ＭＶＣ与ｎｍ２３表达阳性强度呈负相关（ｒ＝－０．５３，Ｐ＜０．０１）．结论：ＭＶＣ和ｎｍ２３基因表达是两个相关联的、可反映人脑胶质瘤生物学行为的有用指标．
Objective: To investigate the clinical significance of microvascular volume (MVC) and nm23 gene expression in human glioma tissue. Methods: The expressions of MVC and nm23 in 54 human glioma tissues were retrospectively studied by immunohistochemistry. Results: The MVC increased with the malignant degree of glioma and the severity of peritumoral edema. MVC in recurrence group was significantly higher than that in non-recurrence group (P <0.01). At the same time, it was found that the positive expression of nm23 was negatively correlated with the malignancy of human glioma and the edema of the tumor (r = -0.48 and -0.51, respectively, P <0.01). The positive expression rate of nm23 in recurrence group was significantly (P <0.05), and there was a negative correlation between the expression of MVC and the positive expression of nm23 in tumor tissue (r = -0.53, P <0.01). Conclusion: MVC and nm23 gene expression are two useful indicators that can reflect the biological behavior of human glioma.