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应用细胞内记录，研究了豚鼠腹腔神经节（ＣＧ）细胞非胆碱能迟慢兴奋性突触后电位（ＬＳ－ＥＰＳＰ）与５－羟色胺（５－ＨＴ）及Ｐ物质（ＳＰ）的相互关系。当重复电刺激内脏大神经（ＳＮ）时，有７８．２％的细胞（１６１／２０６）在动作电位发放后出现ＬＳ－ＥＰＳＰ，灌注或压力注射５－ＨＴ或ＳＰ，分别在６８．５％的细胞（１０２／１４９）及５２．１％的细胞（９８／１８８）上引起５－ＨＴ或ＳＰ去极化反应，两者差异非常显著（Ｐ＜０．０１）；大部分具有ＬＳ－ＥＰＳＰ的细胞对５－ＨＴ（７３／８８，８３．０％）或ＳＰ（６８／１１４５９．６％）敏感，而不出现ＬＳ－ＥＰＳＰ的细胞仅有少数对５－ＨＴ（１０／２６，３８．５％）或ＳＰ（１１／３６，３０．６％）敏感，两类细胞的差异非常显著（５－ＨＴ：Ｐ＜０．０００１，ＳＰ：Ｐ＜０．０１）。上述结果支持５－ＨＴ与ＳＰ均作为递质参与ＬＳ－ＥＰＳＰ形成的观点。此外，在１３３个细胞上同时检测了５－ＨＴ与ＳＰ的作用，其中有６６个细胞（４９．６％）对５－ＨＴ及ＳＰ均敏感，提示在ＣＧ细胞，５－ＨＴ与ＳＰ之间可能存在某种机能联系。
Intracellular recording was used to investigate the relationship between non-cholinergic excitatory postsynaptic potential (LS-EPSP) and serotonin (5-HT) and substance P (SP) in guinea pig celiac ganglia (CG) . When repeated electrical stimulation of the visceral large nerve (SN), 78.2% of the cells (161/206) developed LS-EPSP, perfusion or pressure injection of 5-HT or SP at the action potential of 68.5% (102/149) and 52.1% of cells (98/188) caused 5-HT or SP depolarization reaction, the difference was significant (P <0.01); most of the LS-EPSP Of the cells were sensitive to 5-HT (73/88, 83.0%) or SP (68/11459.6%), while cells that did not show LS-EPSP had only a minority of 5-HT (10/26, 5%) or SP (11/36, 30.6%). There was significant difference between the two groups (5-HT: P <0.0001, SP: P <0.01). The above results support the idea that both 5-HT and SP are involved as transmitters in the formation of LS-EPSP. In addition, the effects of 5-HT and SP were examined simultaneously on 133 cells, of which 66 cells (49.6%) were sensitive to 5-HT and SP, suggesting that between CG cells, 5-HT and SP There may be some kind of functional connection.