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多数研究资料表明：在心肌细胞发生氧反常和ｐＨ反常后，Ｈ￣＋一Ｎａ￣＋、Ｎａ￣＋一Ｃａ￣（２＋交换加强是细胞内Ｃａ￣（２＋）超载的重要机制。我们的研究表明，造成细胞Ｃａ￣（２＋）超载的原因，除Ｈ￣＋一Ｎａ￣＋、Ｎａ￣＋一Ｃａ￣（２＋）交换外，尚有Ｈ￣＋一Ｃａ￣（２＋）交换参加．本实验证实，在细胞缺氧１０、２０、３０和４０ｍｉｎ时，经Ｈ￣＋一Ｃａ￣（２＋）交换进入细胞的Ｃａ２＋量占同一时点细胞摄Ｃａ￣（２＋）总量的比率分别为（％）：１０．１±０．５、１２４±０．７、１１．８±０．４和１１．２±０．５、平均值为（％）：１１．４±０．９．当缺氧细胞再复氧后，这一比率显著增加。各时点的比率分别为（％）：２３．７±０．６、２２．３±０．５、２２．１±０．７和２０．５±０．８、平均值为（％）：２２．２±１２。这一结果表明：在ｐＨ反常所致Ｃａ￣（２＋）超载过程中，Ｈ￣＋一Ｃａ￣（２＋）交换的作用不容忽视。
Most studies show that H + + Na + + and Na + + Ca 2+ play an important role in the overloading of intracellular calcium (Ca 2+) in cardiomyocytes after anomalous oxygen and pH anomalies. Our study It is indicated that the reason for Ca 2+ overload in cells is H ~ + Ca 2+ exchange in addition to H ~ + Na ~ + and Na ~ + Ca ~ (2+) exchange. Confirmed that at the cell hypoxia 10,20,30 and 40min, the H ~ + a Ca ~ (2+) into the cell Ca2 + amount at the same time the total amount of cellular Ca ~ (2+) were (% ): 10.1 ± 0.5, 124 ± 0.7, 11.8 ± 0.4 and 11.2 ± 0.5, with an average of (%): 11.4 ± 0.9. After reoxygenation, this ratio increased significantly (%): 23.7 ± 0.6, 22.3 ± 0.5, 22.1 ± 0.7 and 20.5 ± 0.8, Mean (%):. 22.2 ± 12 This result shows that: in the pH due to abnormal Ca¯ (2+) overload during, H¯ + a Ca¯ (2+) exchange effect can not be ignored.