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目的探讨慢性阻塞性肺疾病(COPD)患者支气管管壁厚度与肺功能的相关性。方法选取安岳县人民医院2011—2013年住院COPD患者146例(COPD组),其中高危21例,轻度56例,中度35例,重度34例。选取同期健康体检者50例为对照组。测量支气管管壁横截面的气道壁外径(D)和内径(L),计算管壁内径与外径比值(T/D),管壁面积占总气道总截面百分比(WA%),分析其与肺功能的相关性。结果 COPD组与对照组T/D、WA%比较,差异有统计学意义(P<0.05)。COPD组内比较,中度、重度COPD患者比轻度和高危组患者T/D、WA%高,而轻度和高危组T/D、WA%比较,差异无统计学意义(P>0.05)。T/D与第1秒用力呼气容积(FEV1)呈负相关(r=-0.564,P<0.05),WA%与FEV1呈负相关(r=-0.753,P<0.05)。结论中度和重度慢性阻塞性肺疾病患者支气管管壁厚度较轻度、高危及正常对照组显著增厚,且增厚程度与气道阻塞程度相关。
Objective To investigate the relationship between bronchial wall thickness and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 146 COPD patients were enrolled in Anyue County People’s Hospital from 2011 to 2013, including 21 with high risk, 56 with mild, 35 with moderate, and 34 with severe. Select the same period of 50 healthy subjects for the control group. The outer diameter (D) and inner diameter (L) of the airway wall were measured and the ratio of the inner diameter to the outer diameter (T / D) of the tube wall was calculated. The percentage of total wall area to the total airway cross section (WA% Analyze its correlation with lung function. Results There was significant difference in T / D and WA% between COPD group and control group (P <0.05). The COPD group had higher T / D, WA% than mild and high risk group, but no significant difference between mild and high risk group (P> 0.05) . T / D was negatively correlated with FEV1 (r = -0.564, P <0.05). WA% was negatively correlated with FEV1 (r = -0.753, P <0.05). Conclusions Bronchial wall thickness is moderately and severely chronic obstructive pulmonary disease patients with mild, high risk and normal control group was significantly thicker, and the degree of thickening and airway obstruction related.