论文部分内容阅读
炔羟雄烯异(?)唑(Danazol,DNZ)系人工合成的男性化作用减弱的雄性激素。1986年我院应用该药治疗特发性血小板减少性紫癜(ITP)16例,现将初步结果报道如下。临床资料16例ITP 中男性7例,女性9例,年龄9～64岁,中数年龄43岁。除2例儿童外,余皆为成人。治疗前血小板(BPC)10～69×10~9/L,中数值26×10~9/L。起病仅数日者3例,余均为慢性ITP。初治3例,复治13例。部分病例临床有牙龈出血、鼻衄及月经过多。11例为难治性ITP,病程长,经多种升血小板药物,包括强的松和/或长春新硷等治疗无效或仅短暂有效。1例已经脾切除。治前均经骨髓穿刺检查,符合ITP。治疗前6例作血小板相关IgG(PAIgG)测定(ELISA 法)为12～661ng/10~9血小板(正常值为17～161ng/10~9血小板),4例增高。诊断标准诊断依据为:1.BPC<100×
Danazol (DNZ) is a synthetic, less masculine androgenic hormone. In 1986 our hospital application of the drug treatment of idiopathic thrombocytopenic purpura (ITP) in 16 cases, the preliminary results are reported below. Clinical data 16 cases of ITP in 7 males and 9 females, aged 9 to 64 years, the median age of 43 years. In addition to 2 cases of children, I are all adults. Pretreatment platelets (BPC) 10 ~ 69 × 10 ~ 9 / L, the median value of 26 × 10 ~ 9 / L. Only a few days of onset in 3 cases, I were chronic ITP. Initial treatment in 3 cases, retreatment in 13 cases. Some cases of clinical bleeding gums, epistaxis and menorrhagia. Eleven patients with refractory ITP had long duration and were ineffective or only transiently effective on a variety of platelet-enhancing drugs, including prednisone and / or vincristine. One patient had splenectomy. Pre-treatment by bone marrow biopsy, in line with ITP. 6 cases before treatment for platelet-associated IgG (PAIgG) assay (ELISA method) for 12 ~ 661ng / 10 ~ 9 platelet (normal 17 ~ 161ng / 10 ~ 9 platelets), 4 cases increased. Diagnostic criteria Diagnostic basis: 1.BPC <100 ×