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目的分析比阿培南对丙戊酸钠血药浓度的影响。方法针对临床病例术后使用比阿培南抗感染后出现口肌痉挛泵入丙戊酸钠,其次日检测丙戊酸钠浓度仅为8.53μg/ml。检索相关文献,总结分析比阿培南对丙戊酸钠血药浓度的影响。结果丙戊酸钠无论静脉还是口服给药,与比阿培南联用,丙戊酸钠血药浓度均显著降低,降幅可达42.64%~84.48%。结论丙戊酸钠与比阿培南联用,丙戊酸钠浓度显著降低,临床应避免两者联用。
Objective To analyze the effect of biapenem on plasma concentration of valproate. Methods The clinical trial of bapentadil after oral administration of biapenem was performed after anti-infection with biapenem. The next day, the concentration of sodium valproate was only 8.53μg / ml. Retrieve the relevant literature, summarize and analyze the effect of biapenem on plasma concentration of valproate. Results Sodium valproate, whether intravenous or oral administration, combined with biapenem, plasma sodium valproate concentrations were significantly reduced, a decline of up to 42.64% to 84.48%. Conclusion Sodium valproate combined with biapenem, sodium valproate concentration was significantly reduced, the clinical should avoid the combination of the two.