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动脉内注入大剂量化疗药物并不断透析静脉血(HICCH),能提供更为有效的区域性动脉内药物剂量,其浓度可达正常用量的2～3倍。自1989～1990年,Tulane 大学医学院肿瘤外科曾用 HICCH 治疗25例区域性晚期腹腔肿瘤,计原发或转移性肝癌14例、未能切除的胰腺癌5例、结肠癌等伴腹膜或盆腔转移5例和第Ⅲ期膀胱癌1例,平均年龄为55岁(36～70岁)。先自股动脉插管至肝动脉(肝癌)或腹腔动脉(胰腺癌、腹膜或盆腔病灶),再经隐静脉插管(双腔透析管)至肝静脉上方,上述插管定位均经血管造影和透视指导下完成。双腔透析管连接至一改良型血透析器,每分钟滤率为400～500ml,超滤率为
Intra-arterial infusion of large doses of chemotherapeutic drugs and continuous dialysis of venous blood (HICCH) can provide a more effective regional intra-arterial dose, which can be 2 to 3 times the normal dose. From 1989 to 1990, tumor surgery at Tulane University Medical School used HICCH to treat 25 cases of regional advanced abdominal tumors, including 14 cases of primary or metastatic liver cancer, 5 cases of unresectable pancreatic cancer, colon cancer, and other peritoneal or pelvic cavities. Five cases and one stage III bladder cancer were metastatic, with an average age of 55 years (36 to 70 years). First from the femoral artery to the hepatic artery (liver cancer) or celiac artery (pancreatic cancer, peritoneal or pelvic lesions), and then through the saphenous vein (double-lumen dialysis tubing) to the upper part of the hepatic vein. Complete with perspective guidance. Double-lumen dialysis tubing connected to an improved hemodialyzer with a filtration rate of 400-500 ml per minute, ultrafiltration rate