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Epostane(1)和 azastene(2)是近年来引人注目的二个抗早孕化合物。本文合成了六个1和2的7-甲基衍生物(3～8)。化合物4仍保留抗早孕活性,其余则活性明显减弱。
Epostane (1) and azastene (2) are two anti-early pregnancy compounds that have drawn considerable attention in recent years. Six 1-and 2-methyl derivatives (3-8) were synthesized in this paper. Compound 4 still retained anti-early pregnancy activity, the rest was significantly reduced activity.