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作者利用离体大鼠工作心脏模型,观察了再灌注时给予三磷酸腺苷-氯化镁(ATP-MgCl_2)9×10~(-4)mmol/L,对20 min停灌/再灌注心脏舒缩功能恢复和心肌Ca~(2+)含量的影响作用.再灌注10 min时,再灌注伊始给药组和单纯再灌组主要心功能指标的恢复率分别为:左室发展压(DP)98.8%±7.5%比76.1%±12.7%,+dp/dt_(max)96.9%±7.8%比79.1%±13.3%,-dp/dt_(max)79.9%±11.0%比61.3%±22.8%,等容舒张期心室内压下降时间常数(T)169.3%±45.6%比216.9%±71.4%,每分主动脉流量(aCO)87.3%±6.1%比43.0%±20.2%.两组心肌Ca~(2+)含量为52.55±8.08μg/g·dry wt和80.64±17.37μg/g·dry wt.统计分析结果均示有显著差异(P<0.05或P<0.01).当再灌注20min给药时,则药物作用效果不明显.结果表明:再灌注伊始给予ATP-MgCl_2能明显减轻心肌“迟呆”的程度,这可能和该药具有减轻心肌再灌注损伤的作用有关。
Using the working heart model of isolated rats, the authors observed that the recovery of cardiac systolic and diastolic function after reperfusion with ATP-MgCl 2 9 × 10 ~ (-4) mmol / L during reperfusion was Myocardial Ca 2+ content.The recovery rate of the main cardiac function indexes at the beginning of reperfusion and the reperfusion group were: left ventricular pressure (DP) 98.8% ± 7.5 % Vs 76.1% ± 12.7%, + dp / dt max 96.9% ± 7.8% vs 79.1% ± 13.3%, dp / dt max 79.9% ± 11.0% vs 61.3% ± 22.8% The time constant of ventricular pressure drop (T) was 169.3% ± 45.6% vs 216.9% ± 71.4%, the aorta flow rate was (aCO) 87.3% ± 6.1% vs 43.0% ± 20.2% (P <0.05 or P <0.01) .When the rats were reperfused for 20 minutes, the drug contents were 52.55 ± 8.08μg / g · dry wt and 80.64 ± 17.37μg / g · dry wt respectively The effect was not obvious.The results showed that ATP-MgCl 2 at the beginning of reperfusion could significantly reduce the degree of “retarded” myocardium, which may be related to the effect of this drug in reducing myocardial reperfusion injury.